WebFeb 15, 2015 · EpCAM is a transmembrane glycoprotein, which is primarily expressed in simple epithelia, progenitor cells, normal and malignant stem cells, as well as in … WebOct 25, 2010 · EpCAM has been long known as a tumor-associated antigen highly expressed in a variety of carcinomas (Koprowski et al., 1979).It is used as a marker for aggressive tumors, and has been considered as a potential target for immunotherapy (Osta et al., 2004).In human and mouse, EpCAM is expressed in embryonic epithelia, but the …
Epithelial Cell Adhesion Molecule - an overview - ScienceDirect
WebAug 5, 2024 · The biology of EpCAM and its role are not completely understood but evidence suggests that the expression of this epithelial cell-surface protein is crucial for metastasis-competent CTCs and may not be lost completely during the epithelial-to-mesenchymal transition. In this review, we summarize the most significant advantages … WebNov 15, 2024 · At TJ break sites, EpCAM–claudin-7 complexes on the basolateral membrane become accessible to apical membrane-anchored serine proteinases (MASPs) and the MASPs cleave EpCAM. … inception beginning
EpCAM and the biology of hepatic stem/progenitor cells
WebNov 13, 2024 · Epithelial cell adhesion molecule (EpCAM) is the most frequently expressed tumor-associated antigen; it is overexpressed in the majority of human … WebApr 4, 2024 · Journal Metrics. Communications Biology has a 2-year impact factor: 6.548 (2024), article downloads of 4,666,583 (2024) and 11 days from submission to the first editorial decision. Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca -independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has … See more First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different … See more The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. Cell adhesion EpCAM was first … See more • FAQs on HNPCC Archived 15 August 2007 at the Wayback Machine from the National Institute of Health • GeneReviews/NCBI/NIH/UW entry on Lynch syndrome See more Although it is identified as a cell adhesion molecule, EpCAM does not structurally resemble any of the four major families of cell adhesion molecules, namely cadherins, integrins, selectins, and members of the immunoglobulin super-family. EpCAM is a See more Target for immunotherapy It has been speculated that since EpCAM in normal epithelia is expressed mostly on the basolateral membrane, it would be much less … See more ina stock-tonscheid