site stats

Epcam biology

WebFeb 15, 2015 · EpCAM is a transmembrane glycoprotein, which is primarily expressed in simple epithelia, progenitor cells, normal and malignant stem cells, as well as in … WebOct 25, 2010 · EpCAM has been long known as a tumor-associated antigen highly expressed in a variety of carcinomas (Koprowski et al., 1979).It is used as a marker for aggressive tumors, and has been considered as a potential target for immunotherapy (Osta et al., 2004).In human and mouse, EpCAM is expressed in embryonic epithelia, but the …

Epithelial Cell Adhesion Molecule - an overview - ScienceDirect

WebAug 5, 2024 · The biology of EpCAM and its role are not completely understood but evidence suggests that the expression of this epithelial cell-surface protein is crucial for metastasis-competent CTCs and may not be lost completely during the epithelial-to-mesenchymal transition. In this review, we summarize the most significant advantages … WebNov 15, 2024 · At TJ break sites, EpCAM–claudin-7 complexes on the basolateral membrane become accessible to apical membrane-anchored serine proteinases (MASPs) and the MASPs cleave EpCAM. … inception beginning https://micavitadevinos.com

EpCAM and the biology of hepatic stem/progenitor cells

WebNov 13, 2024 · Epithelial cell adhesion molecule (EpCAM) is the most frequently expressed tumor-associated antigen; it is overexpressed in the majority of human … WebApr 4, 2024 · Journal Metrics. Communications Biology has a 2-year impact factor: 6.548 (2024), article downloads of 4,666,583 (2024) and 11 days from submission to the first editorial decision. Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca -independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has … See more First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different … See more The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. Cell adhesion EpCAM was first … See more • FAQs on HNPCC Archived 15 August 2007 at the Wayback Machine from the National Institute of Health • GeneReviews/NCBI/NIH/UW entry on Lynch syndrome See more Although it is identified as a cell adhesion molecule, EpCAM does not structurally resemble any of the four major families of cell adhesion molecules, namely cadherins, integrins, selectins, and members of the immunoglobulin super-family. EpCAM is a See more Target for immunotherapy It has been speculated that since EpCAM in normal epithelia is expressed mostly on the basolateral membrane, it would be much less … See more ina stock-tonscheid

The tumor-associated EpCAM regulates morphogenetic movements …

Category:Crystal structure and its bearing towards an understanding of …

Tags:Epcam biology

Epcam biology

Epithelial cell adhesion molecule - Wikipedia

WebAug 5, 2024 · EpCAM is a cell-surface transmembrane glycoprotein that is expressed in healthy human epithelial tissues but also in epithelial cancers, cancer stem cells, and … WebEpCAM: structure and function in health and disease. Injection of tumor cells in mice more than 30 years ago resulted in the discovery of an epithelial antigen, later defined as a cell adhesion molecule (EpCAM). Although EpCAM has since evoked significant interest as a target in cancer therapy, mechanistic insights on the functions of this ...

Epcam biology

Did you know?

WebSep 5, 2024 · Cell-surface tumor marker EpCAM plays a key role in proliferation, differentiation and adhesion processes in stem and epithelial cells. It is established as a cell-cell adhesion molecule, forming... WebAbstract: The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ∼40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia express EpCAM at a variable but generally lower level than carcinoma cells. In early studies, EpCAM was …

WebMay 21, 2024 · Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM … WebAug 7, 2014 · EpCAM is expressed on Clara, ATII, and even potentially on tumor-initiating cells ( 20 – 23 ). Moreover, EpCAM, which can be used to isolate mouse lung epithelial cells ( 20 – 22 ), is overexpressed in lung adenocarcinoma ( 24 ), and is being studied as a target for cancer therapy ( 25 ).

WebThe epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of approximately 40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. ... Here, we provide a comprehensive review of the current knowledge on EpCAM biology in relation to ... WebNov 24, 2024 · Ep-CAM: a human epithelial antigen is a homophilic cell–cell adhesion molecule. J. Cell Biol. 1994;125 (2):437-446. Article CAS Google Scholar Trzpis M, McLaughlin PM, de Leij LM, Harmsen MC. Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule. Am. J. Pathol. 2007;171 (2):386-395. Article …

WebMar 31, 2024 · Each discovery in RNA biology [e.g., primer in CRISPR (7, 8), ... Development of a bifunctional aptamer targeting the transferrin receptor and epithelial cell adhesion molecule (EpCAM) for the …

WebStreptavidin-PE was used to place all the lineage marker-positive cells in the PE channel, and EpCAM-APC was used to stain all epithelial cells. At the same time, cells were stained with Annexin V and 7-amino-actinomycin D (7-AAD, PE Annexin V Apoptosis Detection Kit I, BD Biosciences) according to the manufacturer's instructions. ina strehlowWebMay 31, 2024 · EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been primarily addressed as a cell adhesion molecule. With regard to recent … inception bejoWebThe EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells … inception bending cityWebAug 28, 2014 · EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell–cell adhesion via intercellular oligomerization and ... inception betyderWebJan 11, 2009 · Our finding that EpCAM is a potent signal transducer that uses components of the Wnt pathway, with a proven significance for tumour development and cell renewal … ina storm trackinception bewertungWebEpCAM-associated functions relate to cell-cell adhesion, proliferation, maintenance of a pluripotent state, regulation of differentiation, migration, and invasion. These functions can be conferred by the full-length protein and/or EpCAM-derived fragments, which are generated upon regulated intramembrane proteolysis. inception best scenes