Web1 nov. 2024 · HilncBM/BM and Hilnc-knockout mice are resistant to diet-induced obesity and hepatic steatosis through attenuation of the peroxisome proliferator-activated receptor signalling pathway, as Hilnc... Web30 aug. 2013 · Immunotherapeutics that target tumor-associated antigens such as prostate-specific antigen, prostate acid phosphatase, and prostate-specific membrane antigen (PSMA) provide an alternative strategy to kill prostate cancer cells selectively while minimizing the collateral damage to other normal tissues ( 5 – 9 ).
PSMA ligands. Representative structures of peptide-based PSMA …
Web10 mei 2024 · Arazyme, a metalloprotease from the spider Nephila clavata, exerts hepatoprotective activity in CCL4-induced acute hepatic injury. This study investigated the hepatoprotective effects in high-fat diet (HFD)-induced non-alcoholic fatty liver disease-like C57BL/6J mice. The mice were randomly divided into four groups (n = 10/group): the … Web14 apr. 2024 · Notably, in contrast to the evident hepatic steatosis in humanized liver mice without human immune cells (Fig. 6C, top), humanized livers engrafted with human ... IL-6 ligand production, and hepatic IL-6R–GP130 pathway ... leptin receptor is similar to GP130 in that it also activates STAT3 upon binding to its ligand, leptin ... how do you spell binged
Roles of PPARα and PPARγ As Regulator of Free Fatty Acids in ...
WebBoth PSMA and transferrin receptor bind their ligands followed by internalization of the PSMA-bound ligand complex through the clathrin-coated pits [ 11, 12, 13 ]. PSMA and transferrin receptor are expressed on various tumor cells and inhibiting their functions may lead to implications for cancer therapeutics. Web20 nov. 2024 · The PSMA ligand developed based on the Glu-urea-Lys structure was linked to FITC by aminocaproic acid (Ahx) to obtain PSMA-FITC. The new probe was evaluated in vitro and in vivo. Fluorescence microscopy examination of PSMA-FITC in PSMA(+) LNCaP cells, PSMA(−) PC3 cells, and blocked LNCaP cells showed that the binding of PSMA … Web27 sep. 2024 · Together with 18 GBq [ 177 Lu]LuCl 3 solution, the acetic acid solution was added to 250 µg PSMA-I&T or 250 µg PSMA-617 freshly dissolved in 1 mL water and heated at 100 °C for 20 min. After sterile filtration through a 0.2 µm filter, the solution containing [ 177 Lu]Lu-PSMA-I&T was diluted to 15 ml in NaCl/DTPA containing 8% … how do you spell bingo