Mfsd2a inhibitor
Webb19 sep. 2024 · This first strategy of MFSD2a inhibition was recently realized by Ju where tunicamycin conjugated nanoparticles inhibited MFSD2a activity for the transport of chemotherapy into a murine brain . While this approach was used to treat breast metastases in the brain, a similar approach could be used as a delivery strategy for … Webb4 aug. 2024 · MFSD2A is a sodium-dependent lysophosphatidylcholine symporter that is responsible for the uptake of docosahexaenoic acid into the brain1,2, which is crucial for the development and performance of...
Mfsd2a inhibitor
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WebbMFSD2A (FLJ14490, MFSD2) protein expression summary. ... (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation 6. In … Webb15 juni 2011 · MFSD2A has been previously identified in humans as a putative receptor for Syncytin-2, an ancient retrovirus-derived envelope protein that endows placental trophoblast cells with the capability to fuse into syncytiotrophoblasts ( 33 ).
WebbTunicamycin is an N-glycosylation inhibitor that causes endoplasmic reticulum (ER) stress and activates the unfolded protein response. Using a gene trap assay with KBM7 human myeloid leukemia cells, Reiling et al. (2011)found that disruption of the MFSD2A gene negated tunicamycin toxicity. Webb2 jan. 2024 · Moreover, Wnt signaling inhibitor or Mfsd2a deficiency fails to enhance TMZ penetration in tumors from Cav1-deficient mice. Conclusions: These results …
Webb29 maj 2024 · The small molecule Mek1/2 inhibitor, U0126, was added to HBMECs followed by analysis of Erk phosphorylation and Mfsd2a gene expression. Mek1/2 inhibition led to significantly reduced FGF ... Webb21 mars 2024 · The MFSD2B homologue, MFSD2A, has been identified as a lysophosphatidylcholine transporter in endothelial cells of the blood-brain barrier 16. The protein sequence for mouse MFSD2A showed...
WebbThe expression of Mfsd2a, the LPC-DHA transporter, was reduced in the oxygen-induced retinopathy (OIR) model and streptozotocin (STZ) model. In vitro, Mfsd2a overexpression inhibited endothelial cell proliferation, migration and vesicular transcytosis. Moreover, Mfsd2a overexpression in combination with the DHA diet obviously reduced abnormal ...
Webb10 apr. 2024 · 个人简介. 2015年7月获中国科学院上海有机化学研究所有机化学专业博士学位，2015年8月至2024年2月任中国科学院上海有机化学研究所助理研究员。. 2024年2月至2024年6月在斯坦福大学医学院从事博士后研究，2024年8月至11月哈佛大学访问学者。. 2024年6月入职复旦大学 ... jera global marketsWebbSYNC2 establishes an extensive binding interface with MFSD2A, and a SYNC2-soluble fragment acts as a long-sought-after inhibitor of MFSD2A transport. Our work … jera gilmoreWebb29 mars 2024 · MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment. Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis. laman resmi ltmptWebb12 jan. 2024 · Porphyromonas gingivalis significantly inhibited the expression of Mfsd2a To demonstrate the molecular mechanism of P. gingivalis -enhanced BBB permeability, high-throughput sequencing of BMECs... laman resmi kpkWebb6 juli 2024 · Major facilitator super family domain containing 2a (MFSD2A) is constitutively expressed in the ECs of the central nervous system and is the only well-identified molecule that suppresses caveolae-mediated transcytosis in brain ECs ( Andreone et al., 2024 ). laman resmi snmptnWebb18 mars 2024 · Mfsd2a suppresses caveolae-mediated transcytosis to regulate BBB transcellular permeability via controlling lipid composition of BBB endothelial cells. It is … jera global insurance incWebb通过伊文思蓝和白蛋白-Alexa594 的渗漏检测血脑屏障通透性。通过透射电子显微镜 (TEM) 检查 BBB 的超微结构。通过蛋白质印迹和免疫荧光染色定量Cav-1和Mfsd2a，通过蛋白质印迹定量AQP4、PDGFR-β、ZO-1和Occludin。 结果： Storax 0.1 g/kg 治疗对脑损伤没有 … jera global