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Rnf145

WebThe gene view histogram is a graphical view of mutations across RNF145. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict … WebWe find that RNF145 and gp78, independently co-ordinate HMGCR ubiquitination and degradation. RNF145, a sterol-responsive ER-resident E3 ligase, is unstable but accumulates following sterol depletion. Sterol addition triggers RNF145 recruitment to HMGCR and Insig-1, promoting HMGCR ubiquitination and proteasome-mediated degradation.

Inhibition of cholesterol biosynthesis through RNF145-dependent ...

WebPredicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to … WebLearn more about Anti-RNF145 Mouse Monoclonal Antibody [clone: 3B5]. We enable science by offering product choice, services, process excellence and our people make it happen. legends of flatpicking guitar https://micavitadevinos.com

Tissue expression of RNF145 - Summary - The Human Protein Atlas

WebClones are provided as a live culture in a 2mL tube. Each tube contains LB medium supplemented with 8% glycerol and the appropriate antibiotic. Within 2 to 3 business days … WebMar 21, 2024 · RNF5 (Ring Finger Protein 5) is a Protein Coding gene. Diseases associated with RNF5 include Inflammatory Bowel Disease 7 and Herpes Simplex Virus … WebDec 8, 2024 · Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase. Jiang LY, Jiang W, Tian N, Xiong YN, Liu J, Wei J, Wu … legends of fear shelton connecticut

RNF145 protein expression summary - The Human Protein Atlas

Category:RNF145 ubiquitinates SCAP to inhibit SREBP processing

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Rnf145

Genetic variation of RNF145 gene and blood lipid levels in Xinjiang ...

WebTogether with the previous findings that Rnf145 is an LXR-regulated gene and that RNF145 inhibits the SREBP pathway through ubiquitinating SCAP, RNF145 serves as an important … WebView mouse Rnf145 Chr11:44409791-44456347 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

Rnf145

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WebAug 14, 2024 · We find that RNF145 and gp78, independently co-ordinate HMGCR ubiquitination and degradation. RNF145, a sterol-responsive ER-resident E3 ligase, is … Web丁香通为您提供HumanPDL1pep商品详情介绍：价格：询价，货号：ab45676，品牌：abcam，供应商：abcam，保存条件：+4°C，详见丁香通HumanPDL1pep商品详情页；

WebAug 22, 2024 · RNF145's auto-ubiquitination and degradation are potently inhibited by unsaturated FAs (oleic, arachidonic or eicosapentaenoic acids), allowing RNF145 to … WebDec 13, 2024 · In particular, RNF145 builds up when a cell is starved of cholesterol, but it immediately marks HMGCR for destruction once cholesterol becomes more abundant. …

WebRNF145 ring finger protein 145 0.905653 LOC145783 uncharacterized LOC145783 0.902879 OR2L13 olfactory receptor, family 2, subfamily L, member 13 0.900854 CREM ...

WebApr 1, 2024 · RNF145 is the target gene of miR-362-5p and miR-500b-5p. A, B Possible mRNAs of miR-362-5p and miR-500b-5p were forecast through ENCORI database.

WebDec 13, 2024 · We find that RNF145 and gp78 independently co-ordinate HMGCR ubiquitination and degradation. RNF145, a sterol-responsive ER-resident E3 ligase, is … legends of fox creek clarkstonWebRNF145 Antibody (PA5-57718) in ICC/IF. Immunofluorescent staining of RNF145 in human cell line U-2 OS shows positivity in plasma membrane, cytoplasm & nucleus but excluded … legends offroad williston ndWebOct 27, 2024 · Transduction of RNF145 into mouse liver inhibits the expression of genes involved in cholesterol biosynthesis and reduces plasma cholesterol levels. Conversely, … legends of galactic heroes dubWebOct 25, 2024 · We identify RNF145, an ER membrane ubiquitin E3 ligase with no previously known function, as an inhibitor of hepatic SREBP-2 processing. Expression of Rnf145 is … legends of geist hoa covenantsWebFeb 23, 2024 · Europe PMC is an archive of life sciences journal literature. legends of fort worthWebOct 27, 2024 · Transduction of RNF145 into mouse liver inhibits the expression of genes involved in cholesterol biosynthesis and reduces plasma cholesterol levels. Conversely, acute suppression of RNF145 via shRNA-mediated knockdown, or chronic inactivation of RNF145 by genetic deletion, potentiates the expression of cholesterol biosynthetic genes … legends of gaming wildcardWebFeb 23, 2024 · Regulation of RNF145 by LXR depends on a functional LXR-element in its proximal promotor. Consistent with LXR-dependent regulation of Rnf145 we show that … legends of gaming